Tertullian, who lived from 155 AD until 222 AD wrote:  “For the mystery of iniquity doth already work; only he who now hinders must hinder, until he be taken out of the way.” What obstacle is there but the Roman state, the falling away of which, by being scattered into ten kingdoms, shall introduce Antichrist upon (its own ruins)? “ – Tertullian On the Resurrection of the Flesh chapter 24 

Cyril of Jerusalem (315–386): “But this aforesaid Antichrist is to come when the times of the Roman empire shall have been fulfilled...” First Catechetical Lecture part 15. 

Jerome (347–420): "Says the apostle [Paul in the second epistle to the Thessalonians], ‘Unless the Roman Empire should first be desolated, and antichrist proceed, Christ will not come.’" 
  
John Chrysostom [347-407 AD] “What then is it that withholdeth, that is, hindereth him from being revealed? Some indeed say, the grace of the Spirit, but others the Roman empire, to whom I most of all accede. Wherefore? Because if he meant to say the Spirit, he would not have spoken obscurely, but plainly... But because he said this of the Roman empire, he naturally glanced at it, and speaks covertly and darkly.” – Homily IV. 2 Thess ii. 6-9.